Ayoub WA, Kumar AA, Naguib HS, and Taylor HC
24 However, the GLP-1R is not evidenced in mature osteoblasts, but it is expressed in bone marrow stromal cells (BMSCs)
9 During the day, bone resorption is suppressed, presumably related to food intake and secretion of intestinal-derived hormones, whereas resorption increases at night and during periods of extended fasting ( Figure 2 )
Abo-Elenin, M
Long-Term Efficacy: WW Med+ members prescribed GLP-1s reached a 21% average weight loss at 12 months
Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)