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Follow with sunscreen during daytime use

[17] Secondary constipation Most of medications can lead to constipation as a side effect

PubMed: PM26358288

Moreover, 2.5 mg/kg intragastrically application of cross-linked bromelain with organic acids and polysaccharides (CL-bromelain) for 7 days considerably showed anti-inflammatory effects via reduction of NF-B activity and COX-2 mRNA expression in rat livers (145)

Even though Egger's test was not statistically significant, publication bias cannot be rolled out since positive studies are more likely to be published than negative ones, particularly if they were sponsored by the medication's manufacturer, which is the case for included studies