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This was evidenced by increased alkaline phosphatase (ALP) activity, enhanced mineralization, and upregulation of osteogenic markers such as osteocalcin (OCN) and Runt-related transcription factor 2 (RUNX2)

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4.3 Long-term toxicity concerns The prolonged use of curcumin, particularly at elevated dosages, prompts concerns over its possible toxicological effects

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