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A variant in MC4R , central to satiety and energy balance, works alongside GLP1R the target receptor plus FTO and TCF7L2 in fat mass and glucose regulation

While GLP-1 receptor agonists are not associated with DKA, uncontrolled diabetes can lead to this emergency

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The objective of the SURPASS-2 study was to demonstrate that tirzepatide used at a dose of 10mg or 15 mg once weekly was noninferior to semaglutide 1 mg once weekly, the highest licensed dose available for the management of T2D at the time of SURPASS-2