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This article breaks down that paradox, explains why discomfort is such a powerful biological signal, and shows how intensity shapes everything from lactate metabolism to brain chemistry to long-term resilience

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The author's dual-acting compound addresses this issue: the NMDA receptor antagonist (MK-801) is only activated when the drug binds to and is internalized by the GLP-1 receptor

Clinicians reported having weekly conversations with patients about GLP-1 advertising and increased disordered eating behaviors

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M., Tronieri, J