As its name suggests, DHB is produced by adding a hydrogen ion to the berberine molecule - which is something your body was going to do anyway
In very rare cases, some individuals may experience digestive discomfort with oral supplements
IGF-1 LR3 also acts as a myostatin inhibitor, which helps to prevent muscle breakdown and preserve strength in subjects who may be suffering muscle wasting
You might notice a slight tingling sensation at first, but this is usually normal and should fade within a few minutes
Nazary-Vannani A, Ghaedi E, Mousavi SM, Teymouri A, Rahmani J, Varkaneh HK
Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class