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Physio., 581(pt2), 431-444, 2007
Negrete Velasco A, Ellero A, Ramseier Gentile S, Zimmermann S, Ramaciotti P, Stoll S
All of this is based on some research and my personal experience
On the other hand, low portal insulin levels (e.g., during prolonged fasting) reduce hepatic GHR expression, thereby reducing IGF-1 levels and increasing GH concentrations by the lack of IGF-1 feedback on pituitary GH secretion (Fig