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Specifically, in secretion-competent INS-1E cells and isolated mouse islets (186), butyrate significantly attenuates IL-1- or IL-1/IFN--induced apoptosis by suppressing endoplasmic reticulum (ER) stress, while reducing the production of nitric oxide (NO) and chemokines (CXCL1, CXCL10) that amplify immune cell infiltration
Research focuses include fibroblast migration, collagen production, and nitric oxide modulation
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Storage period after opening: corresponds to the actual storage period
Independently COA verified and HPLC tested
The Phase 2 trial data confirms this: the 1mg dose group achieved only 8.7% weight loss at 48 weeks, indicating that low doses produce modest effects that accumulate slowly
