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Over 68 weeks, each participant received a once-weekly dose of either 2.4 milligrams (mg) of subcutaneous semaglutide or placebo, alongside lifestyle interventions

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GEH10600021) and nitrocellulose membranes (catalogue n GEH10600001) were from GE Healthcare (Milan, Italy)

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This receptor activation results in: Rapid, pulsatile increases in GH secretion Amplification of sleep-related GH peaks Synergistic interaction with Growth Hormone-Releasing Hormone (GHRH) pathways The end result is elevated circulating levels of GH and IGF-1 , which support muscle growth, fat metabolism, and tissue repair