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Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors

Pregnancy Category C: Adequate and well-controlled studies have not been done in pregnant women

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Within the Bliss independence model calculation, synergy is assumed when the actual effect of the combination is greater than the expected effect, i.e., if the Bliss score is greater than 0 (40)

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At the same time, targeted support through protein rich meals, healthy fats, mineral rich foods, vitamin B12, zinc, vitamin D, digestive support, and a personalized plan can change the entire direction of your health