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This contraindication exists because MTC arises from the same C-cells that showed tumor formation in rodent studies, and individuals with MTC history may have underlying genetic susceptibility that could theoretically interact with GLP-1 receptor stimulation

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Journal of Internal Medicine 284, 193210

Endocrinologists classify hypogonadism as primary or secondary depending on whether the dysfunction originates in the testes or the hypothalamicpituitary axis

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J Cereb Blood Flow Metab 17:229232 Nawashiro H, Tasaki K, Ruetzler CA, Hallenbeck JM (1997b) TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice