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Meanwhile, mTORC1, in nutrient-rich conditions, activates forkhead box K1/2 (FoxK1/2) which counters Foxo3-induced activation of autophagy by restricting the acetylation of histone H4 and expression of critical autophagy genes [299]

They undermine what these drugs really are, and are meant to do

Ebanks JP, Wickett RR, Boissy RE

Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib