soul trial oral semaglutide cardiovascular outcomes 2024 (NEJM 2025): led to a 14% ↓ in major CV events vs placebo in T2DM with ASCVD or CKD — no ↑ in serious AEs. #Semaglutide #CardioDiabetes #updatesinmedicine SOUL: Oral Semaglutide Bests Usual

However, several important considerations argue for caution in extending orforglipron to pediatric populations

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Because that is when gastrointestinal effects peak, according to the article

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FAQ Is it safe to take collagen at the same time as my semaglutide injection