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We conclude with details concerning the development and testing of AngIV-based analogs that activate the brain HGF/Met receptor system and show promise as anti-dementia agents in animal models of AD

Excessive supplementation may increase risks without improving results

Circulation 140 , 117125 (2019)

Maintenance doses are typically 1 mg every 2-3 months for life High-dose oral therapy (1000-2000 micrograms daily) may be effective in selected patients with pernicious anaemia under clinical supervision, as passive diffusion can compensate for absent intrinsic factor, though this is not routine first-line treatment in the UK The water-soluble nature of B12 means that high-dose supplementation carries minimal risk of toxicity , making it a safe option for individuals with confirmed or suspected deficiency