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Ipamorelin avoids both issues

However, the native GLP-1 molecule is rapidly degraded by dipeptidyl peptidase-4 (DPP-4) and glomerular filtration and requires modifications to extend its half-life

Jun 27 2019;11(7)doi:10.3390/nu11071466

Chen X, Wu Z, Liu D, Gao Z (2017) Preparation of ZnO photocatalyst for the efficient and rapid photocatalytic degradation of Azo dyes

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Because it bypasses the stomach and intestines, a larger percentage of the dose becomes available to your body compared to oral supplements