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Some studies report significant reductions in TNF- and CRP with GLP-1 RA therapy compared to placebo or other antidiabetic medications (6, 15, 17, 18), while others show non-significant or conflicting results (19, 20)

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At standard dosages (1 to 2 mg per day), the risk is negligible

In an aspect of second embodiment, present invention involves the preparation of fusion tag construct of Formula (II) comprising fusion of amino terminal of a synthetic nucleotide of semapeptide with carboxyl terminal of fusion tag construct