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The theory proposes that some individuals may have difficulty breaking down lectins, leading to impaired digestion, nutrient absorption, gastrointestinal inflammation, disruption of the gut microbiome, and potentially contributing to leaky gut and systemic inflammation, which could trigger autoimmune issues

In mice, activating these neurons led to reduced food intake and fat loss, mimicking the drugs benefits

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These interviews have been lightly edited for clarity

Acylation of ghrelin, which is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT), is required for ghrelin to bind to GHS-R1a (Yang et al., 2008)

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