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doi: 10.1007/s10517-015-2847-3

Use of acetaminophen dramatically increased in the United States in the 1980s due to a concern over an association of aspirin with Reyes syndrome, although a number of critics reject this hypothesis

10.1097/GCO.0000000000000708 25 HonardoustP.NajafpourA.MohammadiR

As such, it is possible that redox-associated extrahepatic mechanisms may contribute to the activation of the hepatic AMPK pathway