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Testosterone is nowhere to be found in this second pathway

To explain why adolescents are more vulnerable to developing substance use disorders than adults

2.4 Effects of metabolism on immune cells in the TME Tumor-infiltrating immune cells have dual characteristics, some of which have the function of inhibiting tumor proliferation and metastasis, such as CD8+ cytotoxic T cells, natural killer (NK) cells, M1 macrophages, dendritic cells (DCs), etc., while others may be beneficial to tumor development, including Treg cells, M2 macrophages (78)

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The CYP450 pathway has the ability to metabolize arachidonic acid into epoxyeicosatrienoic acid (EET) and hydroxyeicosatetraenoic acid (HETE) [65]