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pH Buffer (Optional): A small amount of citric acid or sodium hydroxide may be needed to balance pH to 4.55.5, the skin's natural range

doi:10.1074/jbc.R800046200 Burczynski ME, Sridhar GR, Palackal NT, Penning TM (2001) The reactive oxygen speciesand Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha, beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene

(2007) Expression of Nrf2 in neurodegenerative diseases

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Independent groups working with aging human fibroblasts have reported something genuinely tantalizing: in late-passage cells, the ones that have divided many times and started to look worn, GHK exposure can shift gene-expression patterns partway back toward a younger profile

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