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found that CD8 + T cells hardly express asparagine synthase (ASNS) during the early stage of CD8 + T cell activation and that the growth, activation, and metabolic reprogramming of CD8 + T cells are disrupted in the context of Asn deprivation

A total of 71 eligible studies, comprising 7360 CRC cases and 15982 controls, were included

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They consist of several transmembraneous (Nox1-5, p22phox) and regulatory cytosolic subunits (p47phox, p67phox, rac, Noxo1 and Noxa1)