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These data offer an additional mechanism for GLP-1R signaling regulation of the reinforcing and rewarding properties of cocaine without precluding the possibility that GLP-1R signaling may also affect DA release and firing properties of VTA neurons

Semaglutide (brand names Ozempic and Wegovy) is an FDA-approved GLP-1 receptor agonist that directly reduces appetite, slows gastric emptying, and improves insulin sensitivity

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