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doi: 10.1038/s41467-018-05470-4 15

Guanfacine specifically targets the HCN channels, preventing them from opening, allowing signaling in the brain to not be obstructed by them

Often paired with IV therapy for additive benefit

At 2.5mg/mL, 40 units equals 1mg

Biotin-responsive basal ganglia disease should be renamed biotin-thiamine-responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of 18 new cases