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demonstrated dose-dependent proliferation effects on cultured human dermal papilla cells exposed to GHK-Cu at physiologically relevant concentrations.3 Subsequent work has confirmed that this effect translates into upregulation of genes associated with anagen-phase activity including VEGF, FGF-2, and IGF-1, the three growth factors most directly implicated in hair-cycle regulation

Testing IGF-1-induced expression in this cell line revealed a significant upregulation of PD-L1 surface expression (Supplementary Figure S5D), indicating that the IGF-1PD-L1 axis is not restricted to prostate cancer but may extend to other malignancies

However, the findings of this meta-analysis should be explained cautiously due to remarkable heterogeneity of the included IVF patients (227)