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Med Res Rev 25 : 261309

43 The relevance of this pathway for tumorigenesis is demonstrated by the fact that humans with the Laron syndrome, a recessively inherited defect in the growth hormone receptor, display extremely low IGF-1 and reduced insulin concentrations and usually do not develop cancer despite high prevalence of obesity and dyslipidemia

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However, given that liver-specific knockouts of igf-1 develop subtle growth defects at a much later postnatal age, basal levels of circulating IGF-1 seem to be necessary for the overall process of skeletal growth

Intravesical potassium sensitivity in patients with interstitial cystitis and urethral syndrome