References Graf, M., et al
The role of SIRT1 on DNA damage response and epigenetic alterations in Cancer
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Novo Nordisk are leaning heavily into their oral formulation of Semaglutide, Rybelsus , (Oral formulations face their own unique challenges due to the requirement to avoid extensive degradation of the drug by the digestive system), which although shows less weight loss compared to other competitors, has the convenience of not requiring injections
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However, it has also been observed that hormone-induced phosphorylation of serine 10 in H3 histone (H3S10) prevents the rapid remethylation of the preceding lysine, serving as the metronome of the process and giving the DNA damage repair system enough time to eliminate the oxidized nucleotides from nearby DNA 143
