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In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]

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Nat Rev Endocrinol (2023) 19(4):20116

Tony George , Claudia Fredolini, Francesco Meani, Barney Bishop, Weidong Zhou, Alexis Patanarut, Alessandra Luchini, Emanuel Petricoin, Lance Liotta, and Caterina Longo