In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 1992
Glazenburg EJ, Jekel-Halsema IM, Scholtens E, Baars AJ, Mulder GJ
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Tirzepatide activates both GLP-1 and GIP receptors, creating a different pharmacologic profile that some colitis patients tolerate better because it may produce less pronounced slowing of gastric emptying
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