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N Engl J Med 326:22, 1992 The effect of impaired glucagon suppression on plasma glycemia is dependent on insulin Glucagon Glucagon Insulin Non-diabetic Diabetic HGP Glucose Glucose HGP Non-diabetic Diabetic AJP 277:E283;1999 Placebo Exenatide 0.10 g/kg sc 0 60 120 180 Time (min) Exenatide or placebo Exenatide Reduces Postprandial Glucagon Secretion in Patients With Type 2 Diabetes Meal 200 150 Plasma Glucagon (ng/L) 100 50 0 N = 20.Mean (SE)

Compounded semaglutide products are not FDA-approved and may be prescribed only when clinically appropriate and obtained from properly licensed compounding pharmacies in accordance with applicable laws and regulations

Studies were included if CR, EX or CREX was one of the interventions

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note 18.2% discontinuation from GI/dysesthesia effects

To ensure disposal, you can reach out to local pharmacies or law enforcement agencies for guidance