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In the UK, new medicines must receive a marketing authorisation from the MHRA before they can be legally prescribed or dispensed

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only two studies met or approached this threshold (El-Nahas et al., 2020

Na discusso cientfica sublinha-se que um sinal pulstil preserva melhor a regulao natural do eixo do que uma saturao contnua do sistema

(24381240) Effect on valproate: Phenytoin may induce the metabolism of valproate, thereby lowering valproate levels

doi: 10.1038/s41467-022-31829-9 87 OlesonBJMcGrawJABroniowskaKAAnnamalaiMChenJBushkofskyJRet al