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Melanotan-2 remains the more pharmacologically diverse compound with broader melanocortin effects including tanning, but its lack of regulatory approval and wider side effect profile reflect its status as an unrefined parent compound

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ICIs including monoclonal antibodies against cytotoxic T-lymphocyte antigen-4 or programmed death-1 (PD-1) or its ligand PD-L1 exert antitumour effects by eliciting immune reactions against cancer cells

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