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Signs include dark urine, decreased urination frequency, dizziness upon standing, and dry mucous membranes

SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria

Biochemical analysis Serum urea and creatinine levels While the serum urea level of the MTX group significantly decreased, the serum creatinine level significantly increased compared with the control group (Table 2)

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This represents the first instance of a GLS inhibitor being applied to enhance tumor cell copper death and immunotherapy [154]