Methods: We did a 40-week, randomised, active-controlled, parallel-group, double-blind, phase 3B trial (SUSTAIN FORTE) at 125 outpatient clinics in ten countries
Effects on Muscle Mass Muscle mass plays a critical role in glucose management, as well as in the prevention and management of diabetes and other metabolic conditions
This underscores the need for both RWE and RCTs in parallel and reinforces the need to need to run clinical trials that reflect real-world populations, a topic explored in more detail in our blog Obesity trials on trial Some health improvement seen with GLP-1 therapy may be a direct effect of weight loss, rather than unique drug effect as seen by improvements in liver and kidney health 4
Injection formulations deliver 100% of the dose directly into the bloodstream, matching the clinical trial evidence showing 22% average weight loss
For example, if you inject 5 mg once weekly and your vial contains 30 mg with a 28-day BUD, you have enough medication for 6 weeks but only 4 weeks of guaranteed stability
Outside that narrow case, HSA-or-FSA-funded flat cash-pay (PlexusDx Microdose GLP-1 Protocol at $129/mo, Semaglutide Injection at $189/mo) is mathematically cheaper than financed retail every time
