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When melasma worsens after treatment, the most common reasons are usually: treatment that is too aggressive use of heat-based devices poor aftercare inadequate sun protection That is why professional treatment and a strong maintenance plan matter so much

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This is not extrapolation from animal models there is direct human evidence for the skin and healing claims

Sugiura K (2022) Role of interleukin 36 in generalised pustular psoriasis and beyond

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