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In a 2018 double-blind trial of 100 depressed patients, 1,000 mcg/day adjunct therapy lifted mood scores by 35% after 3 months, outperforming antidepressants alone

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An individual may opt to switch from compounded semaglutide to brand-name Ozempic for improved safety, reduced risk of contaminants, and greater dosage accuracy, says Jana Mowrer, RDN, MPH, CDCES, a certified diabetes specialist, board-certified health coach, and owner of HealthWins with Jana in Fresno, California

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Severe dehydration, acute kidney injury, scheduled surgery, or contrast dye procedures warrant a metformin pause