humanized glp-1 receptor knock-in mouse The Obesity Science & Innovation 2025: Generation of GIPR Mice for Obesity and Diabetes Preclinical Human GLP1R mice | Gene

and Dorothy R

In the LEADER trial, liraglutide demonstrated cardiovascular benefit, and GLP1RAs have similar effects, aligning with liraglutides anti-atherosclerotic effect

The inhibitory effect of GLP-1 on gastric emptying is dose-dependent, and the use of lower doses of GLP-1 in patients with T2DM may also be suitable for blood glucose control (141)

Ganta says she considers her patients specific health profiles before prescribing GLP-1s, especially with older adults who have frailty, dementia, or another geriatric syndrome

It may also help identify permeation enhancers and novel drug candidates for advanced transdermal patches in applications, including diabetes, weight management, and others

1 Rubio M, et al