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Several in vitro and in vivo experimental studies reported that SUN induces its cardiotoxicity by several mechanisms [8,9,10,11,12,13]

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Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action

Additionally, M2-associated iron recycling pathways (HMOX1 upregulation, heme metabolism) can be targeted to shift intracellular iron pools toward pro-ferroptotic states

, cytosolic versus mitochondrial pools), and the surrounding metabolic and enzymatic environment

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