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Anxiety and Hyper-arousal: By boosting GABA, serotonin, and dopamine, it calms the central nervous system, reducing the constant feeling of being "wired and tired" that plagues ME/CFS patients

doi: 10.1186/s40478-021-01180-z 229 YangYZhangJMaDZhangMHuSShaoSet al

Many of these trials will end with data expected late 2024 and into 2025

Your skins main job is to be a barrier - to keep things out

Some ingredient formulations are more easily absorbed and bioavailable (reflecting how much of a nutrient your body can use after eating or taking a supplement)