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For example, 225 mg/day was used in the 6-month study, and 300 mg/day (in divided doses) in some others

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The liver processes these substances in two distinct stages, known as Phase I and Phase II detoxification

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

& Massaro, E

There is a lack of consensus regarding the clinical significance of CST-III microbiota