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doi: 10.1371/journal.pntd.0001704 169 Medicine/Clinical/Trial.gov USNLo

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Metabolic Effects of DPP-4 Related to Its Enzymatic Activity Despite DPP-4 having a relatively restricted substrate preference (Figure 1), a large number of peptides, proteins, and chemokines still fulfill the criteria and could be predicted to be suitable substrates, and indeed, many have been shown to be cleaved by DPP-4 in pharmacological kinetic, in vitro or animal studies, often using high substrate concentrations (3638)