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313,314,315,316,317 Consistently, several established animal models of ASD, including the naturally occurring BTBR strain ( Bifidobacterium and Blautia flora ), MIA model offspring ( Clostridium ), 318,319 VPA-treated rodents ( Desulfovibrionales ) 320,321 and mice lacking the synaptic adhesion protein SHANK3 ( Lactobacillus reuteri ), 322,323 all show disturbance of the intestinal flora