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5,70 The main function of PARP1, another NAD + -consumer enzyme, is DNA repair, but it is also involved in cell proliferation, cell cycle regulation, gene transcription, inflammation, and cell fate

Strategies to reduce oxidative stress, such as maintaining a diet rich in antioxidants, regular exercise, and adequate sleep, are crucial for protecting brain cells and preserving cognitive health over time

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The practical takeaway: AOD-9604 has a clean safety profile in trials but a failed Phase 2b efficacy endpoint