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Antonio Brunetti Ali A Rizvi, 1 Manfredi Rizzo 2 1 Department of Medicine, University of Central Florida College of Medicine, Orlando, Florida, USA

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Abstract Aims/hypothesis Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans

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The reverse conversion chart from tirzepatide to semaglutide follows similar approximations but adds the complexity of losing GIP receptor stimulation