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What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

In the case of L-carnitine, the evidence is mixed : some trials and reviews find modest changes in certain indicators, while others show no relevant differences

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