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A melanotic macule can also become noticeable suddenly, though it may have been developing gradually

In contrast, vitamin B12 levels did not change significantly (p=0.36), suggesting minimal impact on B12 status

References Feier CVI, Vonica RC, Faur AM, Streinu DR, Muntean C

Long term exposure to toxins such as pesticides or heavy metals - glutathione is needed for detoxification

The rash was raw and painful

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