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Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

Cost is the top reason people cant stay on these medicines: in a KFF Health Tracking Poll (2025), more than half of GLP-1 users (56%) said the medicines were difficult to afford , even with insurance, which is why Trimis flat $99$125/month cash price matters

Specifically, this study conducted an automated systemic amino acid scanning of the peptide backbone of semaglutide (Figure 1)

doi: 10.1007/s13399-022-03190-w 277 YiC.HuangS.ZhangW.GuoL.XiaT.HuangF.et al