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Retatrutide is a triple agonist meaning it targets three hormones: GLP-1, GIP, and GCG

doi: 10.1016/j.chemphyslip.2016.12.007

5 Therefore, long-acting GLP-1 RAs are contraindicated in patients with a personal or family history of MTC and in patients with multiple endocrine neoplasia syndrome type 2

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Its long half-life means the medication remains active in blood and tissues for weeks, continuing to influence appetite, blood sugar, and lab values well after the last dose

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