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This high-stakes environment puts enormous pressure on stakeholders to innovate quickly while also preparing for what comes next: reinvention as biosimilars and new competitors disrupt the landscape

The problem, however, was that the molecules half-life was much too short to serve as a useful medicine

Tirzepatide induced larger reductions in body weight vs GLP-1 RAs, ranging from 1.68 kg (95% CI 0.84, 2.52 [ I 2 0%]) with tirzepatide 5 mg to 7.16 kg (95% CI 4.86, 9.46 [ I 2 72%]) with tirzepatide 15 mg (Fig

Even a five to 10 percent reduction in body weight meaningfully improves blood sugar levels, cholesterol, blood pressure and sleep apnea, she adds

The researchers who get the best results and the lowest cost per effective dose are the ones who treat storage as a critical part of their protocol, not an afterthought

But doctors say comparing the two is like comparing apples and oranges