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Figure 7 MRI example showing a normal appearing meniscus

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For Novo Nordisk, the path forward involves both the regulatory decision expected in late 2026 and the data from higher-dose and extended trials over the following year

LOX is a non-heme iron-dependent dioxygenase that can directly oxidize PUFA and PUFA-PLs in membranes, leading to ferroptosis [36]

Next, we investigated whether ER is involved in regulating ferroptosis by silencing ER in ER+ breast cancer cells (Fig