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Studies suggest that GLP-1RAs dont adversely affect bone mineral density and may be associated with a reduced risk of fractures [14]

For example, while the absence of functional GHR was reported to cause an increase in systemic GH levels, a decrease in circulating IGF-1 level (but still present), and a delay in puberty onset with a reduced number of ovarian follicles, these animals could still reproduce, but with a smaller litter size (2124)

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